The Synthesis of Cyclonucleotides with Fixed Glycosidic Bond Linkages as Putative Agonists for P2-Purinergic Receptors |
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| Authors: | Girolamo Tusa Juta K Reed |
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| Institution: | Department of Chemistry , University of Toronto at Mississauga , 3359 Mississauga Rd., Mississauga, Ontario, L5L 1C6 |
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| Abstract: | Abstract Cyclonucleotides with fixed glycosidic bond linkages were investigated as possible ligands for purinoceptors in PC12 cells. P2Y2-purinoceptors were not activated by the ATP analogue, 8,2′-thioanhydroadenosine-5′-triphosphate (4) and only weakly by the UTP analogue, 2,2′-anhydrouridine-5′-triphosphate (6). However, both analogues were agonists for P2X2-purinoceptors although the potencies were approximately 30-fold less than that of the parent nucleotides. |
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