Adenosine Kinase from Rat Liver: New Biochemical Properties |
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Authors: | R Leoncini D Vannoni A Santoro S Giglioni R Carli E Marinello |
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Institution: | Department of Internal Medicine , Endocrine-Metabolic Sciences and Biochemistry University of Siena , Siena, Italy |
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Abstract: | Adenosine kinase is a well-known enzyme which catalyzes the phosphorylation of adenosine to AMP: Its metabolic and kinetic properties are well studied. Here, we report new properties of rat liver enzyme, demonstrating a new reaction: ADP can be a phosphate donor instead ATP, according to the reaction: adenosine + ADP → 2AMP) demonstrating the efficiency of AdK to phosphorylate adenosine, also starting from ADP. Cells could exploited this property in situations in which ATP levels are strongly decreased and ADP decreases slowly. |
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Keywords: | Adenosine kinase Purine metabolism Adenosine ADP |
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