[2,1-c] [1,4]Benzodiazepine (PBD)-Distamycin Hybrid Inhibits DNA Binding to Transcription Factor Sp1 |
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| Authors: | P. G. Baraldi B. Cacciarit A. Guiotto R. Romagnoli G. Spalluto A. Leoni |
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| Affiliation: | Dipartimento di Scienze Farmaceutiche , Università di Ferrara , 44100, Ferrara, Italy |
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| Abstract: | Abstract We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions. |
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