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Synthesis of 2′-Amino-LNA Purine Nucleosides
Authors:Jacob Ravn  Christoph Rosenbohm  Signe M Christensen  Troels Koch
Institution:1. Santaris Pharma A/S , H?rsholm, Denmark;2. Santaris Pharma A/S , H?rsholm, Denmark;3. Novo Nordisk A/S , DK-2760, M?l?v, Denmark
Abstract:The first reported synthesis of 2′-amino-LNA purine nucleosides via a transnucleosidation is accomplished enabling the preparation of oligonucleotides incorporating 2′-amino-LNA with all four natural bases.
Keywords:Amino-LNA  LNA  Transnucleosidation
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