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Synthesis and Biological Activity of Mustard Derivatives of Thymine |
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| Authors: | Amel Hadj-Bouazza Karine Teste Ludovic Colombeau Vincent Chaleix Rachida Zerrouki Michel Kraemer |
| Institution: | 1. Université de Limoges, Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques Limoges , France;2. Laboratoire d’Oncologie Cellulaire et Moléculaire , EA 3410, UFR-SMBH, Université Paris XIII , Bobigny, France |
| Abstract: | The synthesis and biological activity of a novel DNA cross-linking antitumor agent is presented. The new alkylating agent significantly inhibited cell proliferation, migration and invasion as tested in vitro on the A431 vulvar epidermal carcinoma cell line. |
| Keywords: | Nitrogen mustards DNA-cross-linking anticancer thymine microwave |