Synthesis of Carbocyclic 2-Substituted Adenine Nucleoside and Related Analogs期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of Carbocyclic 2-Substituted Adenine Nucleoside and Related Analogs

Authors:	Fazila Zulfiqar Hiroharu Kojima Masayuki Nakanishi Takayuki Ando Yukio Kitade

Affiliation:	1. Department of Biomolecular Science , Faculty of Engineering Gifu University , Gifu , Japan;2. Department of Biomolecular Science , Faculty of Engineering Gifu University , Gifu , Japan;3. Center for Emerging Infectious Diseases , Gifu University , Gifu , Japan;4. Center for Emerging Infectious Diseases , Gifu University , Gifu , Japan;5. Center for Advanced Drug Research , Gifu University , Gifu , Japan;6. United Graduate School of Drug Discovery and Medical Information Sceinces , Gifu University , Gifu , Japan

Abstract:	2-Iodonoraristeromycin, 2-iodoaristeromycin and related analogs were synthesized to investigate their inhibitory activities against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolases.

Keywords:	2-Iodonoraristeromycin 2-Iodoaristeromycin S-adenosyl-L-homocysteine hydrolase 2-modified carbocyclic nucleoside enzyme inhibitor