Design,Synthesis and Anti-HIV Activity of Homologous PMEA Derivatives |
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| Authors: | Chang Hyun Oh Joon Hee Hong |
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| Institution: | 1. Medicinal Chemistry Research Center , Korea Institute of Science and Technology , Seoul , Republic of Korea;2. BK21-Project Team, College of Pharmacy , Chosun University , Kwangju , Republic of Korea |
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| Abstract: | This article describes an efficient route for synthesizing novel cyclopropyl homologous PMEA analogues. The condensation of the bromide 8 with nucleosidic bases (A, U, T, C, 5-FU, G) under standard nucleophilic substitution and deprotection conditions, afforded the target phosphonic acid analogues 14～18 and 21. These compounds were evaluated for their potential antiviral properties against various viruses. Guanine derivative 21 showed significant antiviral activity. |
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| Keywords: | Homologous PMEA acyclic nucleoside antiviral agent |
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