Inhibition of Cell Growth and Proliferation in Human Glioma Cells and Normal Human Astrocytes Induced by 8-Cl-cAMP and Tiazofurin |
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| Authors: | M Pesic K Drabek C Esler S Ruzdijic V Pejanovic Z Pietrzkowski |
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| Institution: | 1. Institute for Biological Research, Department of Neurobiology and Immunology, Laboratory of Molecular Neurobiology , 29. Novembra 142, 11060, Belgrade, Yugoslavia;2. ICN Pharmaceuticals, R &3. D , 3300 Hyland Avenue, Costa Mesa, California, 92626, USA |
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| Abstract: | Abstract 8–Cl-cAMP and tiazofurin (TR) are anti-tumor agents that besides their antiproliferative effect, also induce differentiation of tumor cells. Although, these agents exert a profound effect on the same events of tumor cell life, it is thought that 8-Cl-cAMP and TR act by modulating the signal transduction pathway through distinct mechanisms. We have compared their effect on two human glioma cell lines (U87 MG and U251 MG) and examined if there is selectivity in their action toward normal human astrocytes. |
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