Conformational Changes of DNA by Photoirradiation of DNA-Bis(ZnII-Cyclen)-Azobenzene Complex |
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| Authors: | Kenji Maie Mitsunobu Nakamura Kazushige Yamana |
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| Affiliation: | Department of Materials Science and Chemistry , University of Hyogo , Hyogo , Japan |
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| Abstract: | Bis(ZnII-cyclen)-azobenzene derivative, which has two ZnII-macrocyclic tetraamine complexes connected through azobenzene spacer, has been synthesized as a cross-linking agent for double stranded DNA in aqueous solution. The ZnII-cyclen derivative selectively binds to A-T base pairs producing complexes between the ZnII-cyclen moiety and the imide-deprotonated thymine with breaking A-T base pairs. The azobenzene spacer undergoes cis/trans photoisomerization in the complex between the ZnII-cyclen derivative and the DNA duplex. The conformation of the DNA remarkably changed by photoisomerization of the azobenzene linker, when the ZnII-cyclen derivative binds to the DNA duplex with an interstrand cross-linking manner. |
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| Keywords: | ZnII-cyclen Azobenzene Photoisomerization Conformational change |
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