Nucleolipids as Potential Organogelators |
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| Authors: | Helmut Rosemeyer Eva-Maria Stürenberg Piet Herdewijn |
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| Institution: | 1. Organische Chemie I—Bioorganische Chemie, Institut für Chemie, Universit?t Osnabrück , Osnabrück , Germany;2. Katholieke Universiteit Leuven, Department Farmaceutische Wetenschappen, Afd. Medicinale Chemie , Leuven , Belgium |
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| Abstract: | Four different series of nucleolipids or bola-nucleolipids were synthesized or re-synthesized. Most of the compounds were studied with respect to their gelation properties toward either water or aromatic, hetero-aromatic, and aliphatic hydrocarbons. Bola-nucleolipids 6 and 7 do not gelate any solvent tested, neither as sole additive nor by adding up to 10 wt% of a 1:1 mixture. The nucleolipid 22 carrying the antiviral acyclovir as a head group proved to be a potent organogelator for aromatic hydrocarbons such as toluene, but not for hetarenes, aliphatic hydrocarbons or water. The mono-tailed nucleolipid 24 exhibits excellent organogelator properties for both aromatic and aliphatic hydrocarbons. These were studied as a function of concentration and temperature. |
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| Keywords: | Organogelator nucleolipid gelation properties |
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