Studies on the Methylation Status of CpG Sequences Located in Promoters of Selected Tumour Suppressor Genes in Breast Cancer Cells |
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| Authors: | K. Fabianowska-Majewska R. Kordek B. Krawczyk |
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| Affiliation: | 1. Department of Biomedicinal Chemistry , Medical University of Lodz , Lodz, Poland;2. Department of Pathology , Medical University of Lodz , Lodz, Poland |
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| Abstract: | In the tested samples of sporadic breast cancer (100 cases), hypermethylation of CpG sequences located in ERα promoter was observed in 62 cases. It correlated with: (i) deficiency of ERα protein in 45%, (ii) hypermethylation of BRCA1 promoter in 95%, and (iii) nonmethylated E-cadherin promoter in 90%. Fifty-eight percent of the patients with nonmethylated E-cadherin promoter (56 cases) did not show metastasis to lymphatic nodes. The analysis of the methylation level of the promoter of ERα, BRCA1, and E-cadherin, frequently connected with their activity, shows that it can be an important parameter in the diagnosis and therapeutic strategies in sporadic breast cancer. |
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| Keywords: | Hypermethylation of gene promoter Breast cancer |
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