Development Of The Novel Drug Releasing System Triggered By Hybridization With Target Sequence |
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| Authors: | F. Nagatsugi Shizuka Nakayama Shigeki Sasaki |
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| Affiliation: | 1. Institute of Multidisciplinary Research for Advanced Materials Tohoku University , Sendai, Japan;2. CREST, Japan Science and Technology Agency;3. Graduate School of Pharmaceutical Sciences , Kyushu University , Fukuoka, Japan;4. CREST, Japan Science and Technology Agency;5. Graduate School of Pharmaceutical Sciences , Kyushu University , Fukuoka, Japan |
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| Abstract: | We have already established the strategy of synchronous activation by hybridization, in which the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, can be generated from its stable precursors, the phenylsulfide derivatives, by a hybridization-promoted activation process with selectivity to cytosine. In this study, this in situ activation system was applied to the method for the drug releasing system triggered by hybridization with the target sequence. |
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| Keywords: | Cross-link drug releasing system oligonucleotides synchronous activation 2-amino-6-vinylpurine FRET |
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