Short and Straightforward Synthesis of Triphosphates of Artificial Nucleobase Pairs Displaying Unconventional Pairing Scheme |
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| Authors: | Anilkumar R Kore Bo Yang Balasubramanian Srinivasan |
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| Institution: | 1. Bioorganic Chemistry Division, Life Sciences Solutions Group, Thermo Fisher Scientific, Austin, TX, USAanil.kore@thermofisher.com;3. Bioorganic Chemistry Division, Life Sciences Solutions Group, Thermo Fisher Scientific, Austin, TX, USA |
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| Abstract: | Concise, facile and efficient synthesis of 5′-O-triphosphates of 6-amino-5-nitro-3-(1′-β-D-2′-deoxyribofuranosyl)-2(1H)-pyridone (dZ) and its Watson-Crick complement 2-amino-8-(1′-β-D-2′-deoxyribofuranosyl)-imidazo1,2a]-1,3,5-triazin-4(8H)-one (dP) is reported using a one-pot synthetic procedure. |
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| Keywords: | Artificial nucleobase nucleoside triphosphate phosphorylation concise synthesis one-pot methodology |
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