cAMP Phosphodiesterase Activity Evaluation in Human Carcinoma of Salivary Glands |
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| Authors: | G. Spoto M. della Malva C. Rubini M. Fioroni A. Piattelli E. Serra |
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| Affiliation: | 1. Department of Applied Sciences of Oral and Dental Diseases , “G. D’Annunzio” University , Chieti, Italy;2. Anatomy and Histopathology, Dental School , University of Ancona , Ancona, Italy |
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| Abstract: | The aim of this study was to evaluate differences of cAMP-PDE activity in human salivary glands, between a control group and some different benign tumours groups and, where present, with 2 malignant tumors groups. The value of the enzymatic activity in the groups analysed was 50% lower than control samples. The differences between the control group (82 ± 7.9 nmols/mg of protein) and the 3 pathologic groups (Benign A: 44 ± 6.2; Malignant A: 40 ± 16; Benign B: 40 ± 14.2; Malign A: 9.1; Benign C: 22 nmols/mg of protein) are statistically significant. |
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| Keywords: | cAMP Carcinoma Cyclic nucleotides Phosphodiesterase Salivary glands |
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