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Synthesis and Antitumor Activity of Fluorocyclopentenyl-Pyrimidines |
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| Authors: | Lak Shin Jeong Long Xuan Zhao Won Jun Choi Shantanu Pal Yeon Hee Park Sang Kook Lee |
| Institution: | College of Pharmacy , Ewha Womans University , Seoul, Korea |
| Abstract: | Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6–9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from d-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines. |
| Keywords: | Electrophilic fluorination ring-closing metathesis oxidative rearrangement Mitsubobu condensation antitumor |