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Synthesis and Biological Evaluation of Acyclic Phosphonic Acid Nucleoside Derivatives |
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| Authors: | Philip Wainwright Adrian Maddaford Xiurong Zhang Helen Billington David Leese Rebecca Glen |
| Affiliation: | Peakdale Molecular Ltd., Chapel-en-le-Frith , Derbyshire , United Kingdom |
| Abstract: | As part of a project to generate a library of nucleosides as potential antiviral agents, a small subset of novel acyclic phosphonic acid nucleosides was prepared. Practical synthetic routes are described for three targets, which were then tested against HIV, hepatitis C virus (HCV), and Dengue virus. |
| Keywords: | Antivirals acyclic phosphonic acid nucleosides |