Synthesis of Quinoxaline Azido and Amino Reverse Ribofuranoside and Their O-Regioisomers |
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Authors: | Ibrahim A. I. Ali |
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Affiliation: | Department of Chemistry, Faculty of Science , Suez Canal University , Ismailia , Egypt |
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Abstract: | A series of quinoxaline azido reverse nucleosides 3a-c and their O-regioisomers 4a-c was prepared by reaction of quinoxaline 1a-c with 3-azido-3-deoxy-1,2-O-isopropylidene-5-p-toluenesulfonyl-D-ribofuranose (2) in the presence of sodium hydride. Structure modification of these interesting structures includes reduction and the subsequent acetylation reactions to give quinoxaline amino and acetyl amino reverse nucleosides and their O-regioisomers. |
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Keywords: | Reverse nucleosides quinoxaline azido sugar amino sugar ribose |
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