Synthesis and antiviral evaluation of novel open-chain analogues of neplanocin A |
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| Authors: | Joon Hee Hong So-Young Kim Chang-Hyun Oh Kyung Ho Yoo Jung-Hyuck Cho Prof Dr |
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| Institution: | 1. College of Pharmacy , Chosun University , Kwangju , Korea;2. Medicinal Chemistry Research Center , Korea Institute of Science and Technology , Seoul , Korea |
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| Abstract: | Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with purine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds Ia – II were evaluated for their antiviral activity against various viruses such as HIV, HSV-1, HSV-2, and ECMV. |
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| Keywords: | Antiviral agents Acyclic nucleosides Neplanocin A |
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