Facile Synthesis of N-(1-Alkenyl) Derivatives of 2,4-Pyrimidinediones |
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| Authors: | Ulla Henriksen |
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| Institution: | Department of Chemistry , University of Copenhagen The H. C. ?rsted Institute , Universitetsparken 5, DK-2100, Copenhagen, Denmark |
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| Abstract: | Abstract N-(1-alkenyl) derivatives of 2,4-pyrimidinediones (6–9) were prepared in a one pot synthesis from aldehydes and the nucleobases using trimethylsilyl trifluoromethanesulfonate (TfOTMS) as coupling reagent. Presilylation of the above nucleobases, and N 6-benzoyladenine, with excess N,O-bis(trimethylsilyl)acetamide (BSA) followed by addition of one mol eq. TfOTMS yielded the N-(1-trimethylsilyloxyalkyl) derivatives 1–5. |
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