3-Substituted Pyrazinone Nucleosides—A New Family of D4T Analogues |
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| Authors: | Nathalie Batoux Robert Granet Rachida Zerrouki Pierre Krausz |
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| Institution: | Université de Limoges, Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques , Limoges, France |
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| Abstract: | The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by 1H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined. |
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| Keywords: | Pyrazinone d4t nucleosides HIV |
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