Design,Synthesis, Antiviral,and Cytostatic Evaluation of Novel Isoxazolidine Analogues of C-Nucleotides |
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| Authors: | Magdalena Grabkowska-Drużyc Jan Balzarini Dorota G Piotrowska |
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| Institution: | 1. Bioorganic Chemistry Laboratory, Faculty of Pharmacy , Medical University of ?ód? , ?ód? , Poland;2. Rega Institute for Medical Research , KU Leuven , Belgium |
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| Abstract: | 5-Aryl-2-methylisoxazolidin-3-yl-3-phosphonates have been synthesised from N-methyl-C-diethoxyphosphorylnitrone and vinyl aryls in good yields. Isoxazolidine phosphonates obtained herein were evaluated for activity against a broad range of DNA and RNA viruses. None of the compounds were endowed with antiviral activity nor cytostatic activity at 100 to 250 μM concentrations. |
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| Keywords: | C-nucleotide analogues phosphonates isoxazolidines 1 3-dipolar cycloaddition |
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