Synthesis,DNA-Binding,and Photocleavage Properties of a Serious of Porphyrin-Daunomycin Hybrids |
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Authors: | Ping Zhao Jia-Zheng Lu Juan He Wan-Hua Chen Pan-Pan Chen Dian-Wen Chen |
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Affiliation: | 1. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, NO. 13, Changmingshui Road, Zhongshan, PR Chinazhaoping666@163.com;3. School of Pharmacy, Guangdong Pharmaceutical University, NO. 280, Waihuandong Road, Education Mega Centre, Guangzhou, PR China;4. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, NO. 13, Changmingshui Road, Zhongshan, PR China |
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Abstract: | It is widely accepted that the pharmacological activities of anthracyclines antitumor agents express when the quinone-containing chromophore intercalates into base pairs of the duplex DNA. We have successfully synthesized and investigated the DNA-interactions of hybrids composed with quinone chromophore and cationic porphyrin. Herein, a clinic anticancer drug, daunomycin, is introduced to the porphyrin hybrids through different lengths of amide alkyl linkages, and their interactions and cleavage to DNA were studied compared with the previous porphyrin-quinone hybrids. Spectral results and the determined binding affinity constants (Kb) show that the attachment of daunomycin to porphyrin could improve the DNA-binding and photocleaving abilities. The porphyrin-daunomycin hybrids may find useful employment in investigating the ligand-DNA interaction. |
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Keywords: | Porphyrin-daunomycin hybrids DNA binding DNA photocleavage |
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