Effect of caffeine and isobutyl-methyl-xanthine on production of binucleate cells and on post-replicative repair. |
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| Authors: | J Grenet C De La Torre J Sans |
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| Affiliation: | Departamento Biomédico, Facultad de la Salud, Universidad de Antofagasta, Chile. |
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| Abstract: | Caffeine (CAF) but not 3-isobutyl 1-methyl-xanthine (IBMX) displayed a strong DNA anti-repair effect in G2 prophase, as estimated by the frequency of abnormal chromosomes in anaphase-telophase found shortly after treatment. IBMX is more effective than CAF in inhibiting cytokinesis, while the binucleate cells formed by a short treatment with any of these two xanthines have similar cycle kinetics. |
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