A molecular orbital study of the metabolic pathway with hydroquinone intermediate from benzene as carcinogen |
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Authors: | Seiji Tani Akira Imamura Katsuya Kanda |
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Affiliation: | (1) Department of Chemistry, Faculty of Science, Hiroshima University, Higashisenda-machi, Naka-ku, 730 Hiroshima, Japan |
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Abstract: | A possible metabolic activation pathway of benzenein vivo is the nonenzymatic oxidation of hydroquinone producedvia the cytochrome P-450-mediate two-step oxidation of benzene. The mechanism of the further oxidation of hydroquinone and the nature of the most reactive intermediate have not yet been clarified, although it is speculated that the intermediate isp-benzoquinone and/orp-benzosemiquinone. The theoretical result of using molecular orbital calculations (ab initio and CNDO/2 methods) indicates that although the mechanism of the nonenzymatic oxidation of hydroquinone cannot yet be determined, the intermediate is thep-benzosemiquinone anion radical. It is also suggested that active-oxygen species such as hydroxyl radical, which accelerates the nonenzymatic oxidation, play an important role in the metabolic pathway in question. |
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