Dose response of Cryptosporidium parvum in outbred neonatal CD-1 mice. |
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Authors: | G R Finch C W Daniels E K Black F W Schaefer rd and M Belosevic |
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Institution: | G R Finch, C W Daniels, E K Black, F W Schaefer, 3rd, and M Belosevic |
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Abstract: | Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies. |
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