Muscle fiber conduction velocity in different gait phases of early and late-stage diabetic neuropathy |
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| Institution: | 1. Laboratory of Biomechanics of Human Movement, Dept. Physical Therapy, Speech and Occupational Therapy, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil;2. Human Performance Laboratory, School of Physical Education and Physiotherapy, Federal University of Amazonas, Amazonas, Brazil;1. Department of Epidemiology and Preventive Medicine, Monash University, School of Public Health and Preventive Medicine, Alfred Hospital, Melbourne, Australia;2. Baker IDI Heart and Diabetes Institute, Melbourne, Australia;3. Department of Medicine, Monash University, Melbourne, Australia;4. University of Melbourne, Department of Medicine, Austin Hospital, Melbourne, Australia;5. Menzies Research Institute, Hobart, Australia;1. Section of Neurosurgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;2. Dardinger Microneurosurgical Skull Base Laboratory, Department of Neurological Surgery, Wexner Medical Center, The Ohio State University, Columbus, Ohio;3. Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan;1. School of Artificial Intelligence, Hangzhou Dianzi University, Hangzhou 310018, China;2. Key Laboratory of Brain Machine Collaborative Intelligence of Zhejiang Province, Hangzhou 310018, China;3. Department of Automation, Zhejiang University of Technology, Hangzhou 310023, China;4. Hangzhou Vocational & Technology College, Hangzhou 310018, China;1. Bioengineering and Biomechanics Laboratory, Universidade Federal de Goiás, Goiânia, Brazil;2. Laboratory of Biomedical Engineering, Universidade Federal de Uberlândia, Uberlândia, Brazil;1. University Outpatient Clinic, Sports Medicine & Sports Orthopaedics, University of Potsdam, Germany;2. Bern University of Applied Sciences, Health, Physiotherapy, Bern, Switzerland |
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| Abstract: | We investigated the muscle fiber conduction velocity (MFCV) during gait phases of the lower limb muscles in individuals with various degrees of diabetic peripheral neuropathy (DPN). Forty-five patients were classified into severity degrees of DPN by a fuzzy model. The stages were absent (n = 11), mild (n = 14), moderate (n = 11) and severe (n = 9), with 10 matched healthy controls. While walking, all subjects had their sEMG (4 linear electrode arrays) recorded for tibialis anterior (TA), gastrocnemius medialis (GM), vastus lateralis (VL) and biceps femoris (BF). MFCV was calculated using a maximum likelihood algorithm with 30 ms standard deviation Gaussian windows. In general, individuals in the earlier stages of DPN showed lower MFCV of TA, GM and BF, whilst individuals with severe DPN presented higher MFCV of the same muscles. We observed that mild patients already showed lower MFCV of TA at early stance and swing, and lower MFCV of BF at swing. All diabetic groups showed a markedly reduction in MFCV of VL, irrespective of DPN. Severe patients presented higher MFCV mainly in distal muscles, TA at early and swing phases and GM at propulsion and midstance. The absent group already showed MFCV of VL and GM reductions at the propulsion phase and of VL at early stance. Although MFCV changes were not as progressive as the DPN was, we clearly distinguished diabetic patients from controls, and severe patients from all others. |
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| Keywords: | Diabetic polyneuropathies Neural conduction Muscle fiber Electromyography |
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