| 肠道菌群影响脊髓损伤后焦虑情绪的研究进展 |
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| 引用本文： | 王青燕,高慧,何盟泽,白心悦,席回林,杨彦玲.肠道菌群影响脊髓损伤后焦虑情绪的研究进展[J].微生物学通报,2023,50(12):5563-5573. |
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| 作者姓名： | 王青燕 高慧 何盟泽 白心悦 席回林 杨彦玲 |
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| 作者单位： | 延安大学医学院, 陕西 延安 716000 |
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| 基金项目： | 榆林市第一医院横向课题(YAU202301791) |
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| 摘 要： | 脊髓损伤作为一种严重的创伤性应激可以引发焦虑情绪，对患者心理健康造成极大影响。研究发现，脊髓损伤后肠道菌群失调与焦虑情绪的发生存在密切联系，因此本文从5-羟色胺系统失调、多巴胺系统失调、脑源性神经营养因子缺乏及炎症反应4个方面，探讨脊髓损伤后肠道菌群改变影响焦虑情绪发生的机制，为今后治疗脊髓损伤后焦虑情绪的深入研究和药物开发提供理论依据。
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| 关 键 词： | 脊髓损伤 焦虑 肠道菌群 |
| 收稿时间： | 2023/5/10 0:00:00 |
Gut microbiota in anxiety after spinal cord injury: a review |
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| WANG Qingyan,GAO Hui,HE Mengze,BAI Xinyue,XI Huilin,YANG Yanling.Gut microbiota in anxiety after spinal cord injury: a review[J].Microbiology,2023,50(12):5563-5573. |
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| Authors: | WANG Qingyan GAO Hui HE Mengze BAI Xinyue XI Huilin YANG Yanling |
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| Institution: | Medical School of Yan''an University, Yan''an 716000, Shaanxi, China |
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| Abstract: | Spinal cord injury as a traumatic stress may trigger anxiety in patients. Studies have shown that intestinal dysbacteriosis is closely related to the occurrence of anxiety after spinal cord injury. This article expounds the mechanisms by which the alteration of gut microbiota affects the occurrence of anxiety after spinal cord injury from four aspects: serotonin system dysregulation, dopamine system dysregulation, brain-derived neurotrophic factor deficiency, and inflammatory response. This review aims to provide a theoretical basis for future in-depth research and drug development for the treatment of anxiety after spinal cord injury. |
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| Keywords: | spinal cord injury anxiety gut microbiota |
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