Investigations on organic fungicides

Summary The antimicrobial spectrum of the antifungal substance tetramethylthiuram disulphide (t.m.t.d.) was determined. The substance in general possessed antifungal rather than antibacterial properties. The bacteria as well as the moulds varied considerably with regard to their sensitivity towards t.m.t.d. Among the moulds the parasitic species were in general more sensitive to t.m.t.d. than the saprophytic fungi.The mode of action of t.m.t.d. was briefly discussed. It was concluded that this substance probably acts by interference with the anabolic part of mould metabolism.