Synthesis of 2-5As possessing base-modified adenosines and their activities to human recombinant RNase L. |
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| Authors: | Y Kitade Y Tanida T Tuboi A Yoshimura M Nakanishi C Yatome |
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| Affiliation: | Laboratory of Molecular Biochemistry, Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan. |
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| Abstract: | The unique 2',5'-oligoadenylate (2-5A) acts as a potent inhibitor of translation in vertebrate cells through the activation of a constituent latent 2-5A-dependent endoribonuclease (RNase L). This 2-5A system plays a major role in the interferon natural defense mechanism against viral infection. We report the syntheses of base-modified adenosine-substituted 2-5A derivatives, their interaction with recombinant human RNase L and their biological stability. |
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