| 药用昆虫蜣螂对灵芝发酵和抗小鼠肝癌活性的影响 |
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| 引用本文： | 刘高强,丁重阳,章克昌,王晓玲. 药用昆虫蜣螂对灵芝发酵和抗小鼠肝癌活性的影响[J]. 生物工程学报, 2009, 25(6): 880-886 |
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| 作者姓名： | 刘高强 丁重阳 章克昌 王晓玲 |
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| 作者单位： | 1. 中南林业科技大学生命科学与技术学院,长沙,410004
2. 江南大学食品科学与技术国家重点实验室,无锡,214122 |
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| 基金项目： | 国家自然科学基金项目(No.30700552)资助~~ |
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| 摘 要： | 采用液体深层发酵方式,研究了药用昆虫蜣螂对灵芝细胞生长、关键活性产物发酵动力学和抗小鼠肝癌活性的影响。结果表明,药用昆虫蜣螂在各添加浓度下对灵芝的细胞生长均无显著促进作用;但在添加量为5g/L时,对灵芝多糖和灵芝三萜的发酵动力学有显著影响(P<0.05),在发酵第7天时,灵芝总多糖和总三萜的产量分别达到2.81g/L和539.0mg/L(对照组分别为2.25g/L和428.2mg/L)。小鼠体内抗肝癌结果表明,灵芝对照发酵物的抑癌率为41.61%,灵芝-蜣螂配合物的抑癌率为42.24%;而补加蜣螂发酵后的灵芝加蜣发酵物的抑癌率高达57.21%,与灵芝对照发酵物的抑癌率相比,提高了37.49%。研究表明,采用昆虫蜣螂补料-分批发酵后,灵芝发酵物抗小鼠肝癌的活性得到显著增强。
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| 关 键 词： | 药用昆虫 灵芝 深层发酵 抗癌活性 |
| 收稿时间： | 2009-02-16 |
Effects of medicinal insect Catharsius molossus on submerged fermentation and in vivo anti-hepatoma activity of Ganoderma lucidum |
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| Gaoqiang Liu,Chongyang Ding,Kechang Zhang and Xiaoling Wang. Effects of medicinal insect Catharsius molossus on submerged fermentation and in vivo anti-hepatoma activity of Ganoderma lucidum[J]. Chinese journal of biotechnology, 2009, 25(6): 880-886 |
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| Authors: | Gaoqiang Liu Chongyang Ding Kechang Zhang Xiaoling Wang |
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| Affiliation: | College of Life Science and Technology, Central South University of Forestry and Technology, Changsha 410004, China;State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China;State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China;College of Life Science and Technology, Central South University of Forestry and Technology, Changsha 410004, China |
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| Abstract: | We studied the effects of Catharsius molossus(a Chinese medicinal insect) on the cell growth,fermentation kinetics of key bioactive substances and anti-cancer activity of Ganoderma lucidum in submerged fermentation.The results showed that C.molossus at all the tested concentrations had no stimulatory effect on the cell growth.However,addition of C.molossus at 5 g/L lead to significant effects on the fermentation kinetics of polysaccharides and triterpenoids of G.lucidum,and at 7th day in fermentation proces... |
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| Keywords: | medicinal insects Ganoderma lucidum submerged fermentation anti-cancer activity |
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