Effect of genistein,a tyrosine kinase inhibitor,on TAME-esterase induced contractions in rat aorta in vitro |
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Authors: | Gurib F B H Subratty A H |
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Affiliation: | Department of Health and Medical Sciences, Faculty of Science, University of Mauritius, Reduit, Mauritius. |
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Abstract: | Effect of genistein, a protein tyrosine kinase inhibitor, on TAME-esterase induced contractions were studied on rat aorta strips in vitro. Data showed that TAME-esterase induced contractions were concentration dependent and these contractions were significantly inhibited when rat aorta strips were pre-incubated with genistein. The present findings provide evidence for the possible contribution of tyrosine kinases during TAME-esterase induced contractions in aorta. |
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