Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides. |
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| Authors: | K Augustyns A Van Aerschot A Van Schepdael C Urbanke and P Herdewijn |
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| Institution: | Rega Institute for Medical Research, Leuven, Belgium. |
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| Abstract: | (S)-9-(3,4-dihydroxybutyl)adenine was used at several positions as nucleoside substitute in the synthesis of dimers and 13-mers. Therefore we used the phosporamidite and the H-phosphonate chemistry. The nuclease susceptibilities and the base-pairing properties of these oligomers have been evaluated. |
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