Parallel and combinatorial approaches for synthesis of ligands |
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Authors: | Lavastre Olivier Bonnette Fabien Gallard Laurent |
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Institution: | Institut de chimie, UMR 6509 CNRS-Université de Rennes1, Campus de Beaulieu 35042 Rennes, France. olivier.lavastre@univ-rennes1.fr |
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Abstract: | Although new detection screening methods must still be developed, the actual main limitation in combinatorial chemistry seems to be the diversity of ligands that can be generated in terms of real structural and chemical diversity. Thus, there is a strong interest for the development of different strategies for the parallel or combinatorial synthesis of ligands. We report here a selection of recent attempts proposing 'open' approaches able to increase the diversity of molecular architecture truly accessible via parallel or combinatorial processes. |
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