| 竹红菌甲素敏化质粒pBR 322 DNA光氧化——使封闭环DNA转变为开环DNA |
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| 引用本文： | 贾弘.竹红菌甲素敏化质粒pBR 322 DNA光氧化——使封闭环DNA转变为开环DNA[J].中国生物化学与分子生物学报,1989,5(4):335-338. |
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| 作者姓名： | 贾弘 |
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| 作者单位： | 北京医科大学生物化学教研室 北京
(贾弘(礻是))，北京医科大学基础医学专业 82级学生
(付毅平)，北京医科大学生物化学教研室 北京(董苍玉) |
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| 摘 要： | 甲素可敏化质粒pBR 322 DNA光氧化断链的使其封闭环DNA转变为开环DNA。甲素敏化pBR 322 DNA光氧化反应可被单线态氧淬灭剂-NaN_3抑制,证明此光敏氧化机制属Ⅱ型过程。
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| 关 键 词： | 竹红菌甲素 DNA光敏氧化作用 单线态氧 |
| 收稿时间： | 1989-08-20 |
Hypocrellin A-sensitized Pnotooxidation of pBR 322 DNA Resulting in Strand Scission to Open Circular DNA |
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| Jia,Hong-ti Fu,Yi-ping Dong,Caug-yu.Hypocrellin A-sensitized Pnotooxidation of pBR 322 DNA Resulting in Strand Scission to Open Circular DNA[J].Chinese Journal of Biochemistry and Molecular Biology,1989,5(4):335-338. |
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| Authors: | Jia Hong-ti Fu Yi-ping Dong Caug-yu |
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| Institution: | (Department of Biochemistry, Beijing Medical University, Beijing |
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| Abstract: | The photooxidation of pBR 322 DNA sensitized by Hypocrellin A resulted in the conversion of closed circular DNA to open circular DNA. This result showed that strand scission of pBR 322 DNA might occur in this photooxidation. Singlet oxgen quencher-NaN3 could protect DNA from strand scission suggesting that Type Ⅱ process was involved in Hypocrellin A-sensitized photooxidation of pBR 322 DNA. |
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| Keywords: | Hypocrellin A Photooxidation of DNA Singlet Oxygen |
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