DISAGGREGATION OF POLYSOMES IN FETAL ORGANS AND MATERNAL BRAIN AFTER ADMINISTRATION OF d-LYSERGIC ACID DIETHYLAMIDE IN VIVO |
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| Authors: | John J Heikkila Larry Holbrook Ian R Brown |
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| Institution: | Department of Zoology, Scarborough College, University of Toronto, West Hill, Ontario MIC 1A4, Canada |
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| Abstract: | The intravenous administration of d-lysergic acid diethylamide (LSD) to pregnant female rabbits induced hyperthermia as well as disaggregation of polysomes in fetal organs and maternal brain. The LSD-induced polysome shift in maternal brain and fetal organs was not due to an activation of ribonuclease or associated with alterations in the levels of free amino acids. Pretreatment with the receptor blocking agents haloperidol and pizotyline blocked both LSD-induced polysome shift in maternal brain and fetal organs and LSD-induced hyperthermia. Fine dissection of adult rabbit brain showed that the extent of LSD-induced disaggregation of polysomes does not exhibit any marked regional variation. |
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