In vitro antitumor activity of N-glycosyl sulfonamides |
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| Authors: | Crespo Rosana de Bravo Margarita G Colinas Pedro A Bravo Rodolfo D |
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| Affiliation: | Instituto de Investigaciones Bioquímicas de La Plata (UNLP-CONICET CCT La Plata), 60 y 120. (1900) La Plata, Argentina. |
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| Abstract: | A series of α-D-hex-2-enopyranosyl sulfonamides was evaluated for their antiproliferative activity against human hepatocellular liver carcinoma (HepG2) and human lung adenocarcinoma (A549) cell lines. The most potent compound (2,4,6-tri-O-acetyl-3-deoxy-α-D-erythro-hex-2-enopyranosyl ethanesulfonamide) showed antiproliferative properties in the micromolar range. The SARs of these sulfonamidoglycoside which includes the influence of carbohydrate rings and sulfonamide class are described. |
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