Schedule dependence of the lethal effects of 6-azauridine and cytosine arabinoside on murine leukemia cels (L5178Y) in culture |
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Authors: | W D Brenckman M Y Chu G A Fischer |
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Affiliation: | 1. Division of Biological and Medical Sciences, Brown University, Providence, R.I., U.S.A.;2. Department of Medicine, Roger Williams General Hospital, Providence, R.I., 02908, U.S.A. |
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Abstract: | The antineoplastic drugs 6-azauridine and cytosine arabinoside exhibit a supra-additive lethal effect on murine L5178Y lymphoblasts if exposure to 6-azauridine precedes exposure to cytosine arabinoside; an additive effect is seen if cytosine arabinoside precedes 6-azauridine, while a sub-additive effect is obtained when the two drugs are present simultaneously. The potentiation of the effect of cytosine arabinoside by 6-azauridine increases for following the removal of the 6-azauridine from the culture. |
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