The cytotoxic interaction of inorganic trace elements with EDTA and cisplatin in sensitive and resistant human ovarian cancer cells |
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| Authors: | Robert H Maier Susan M Purser Daniel L Nicholson Walter J Pories |
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| Institution: | (1) Department of Surgery, School of Medicine, East Carolina University, 27858-4354 Greenville, North Carolina |
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| Abstract: | Summary Cisplatin (CDDP)-sensitive and -resistant human ovarian cells were studied in vitro with the objective of enhancing CDDP cytotoxicity by the addition of a metal and the chelate ethylenediaminetetraacetic acid
(EDTA), to the CDDP. Chelateable elements, such as bismuth, calcium, cadmium, copper, iron, magnesium, selenium, vanadium,
and zinc, when added to CDDP and in the presence of EDTA increased the cytotoxicity of the CDDP as compared to CDDP treatment
alone. |
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| Keywords: | trace metals chemotherapy chelating agents ovarian cancer |
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