Treponema pallidum fibronectin-binding proteins |
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| Authors: | Cameron Caroline E Brown Elizabeth L Kuroiwa Janelle M Y Schnapp Lynn M Brouwer Nathan L |
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| Affiliation: | Box 357185, Department of Medicine, Division of Infectious Diseases, University of Washington, Seattle, WA 98195, USA. caroc@u.washington.edu. |
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| Abstract: | Putative adhesins were predicted by computer analysis of the Treponema pallidum genome. Two treponemal proteins, Tp0155 and Tp0483, demonstrated specific attachment to fibronectin, blocked bacterial adherence to fibronectin-coated slides, and supported attachment of fibronectin-producing mammalian cells. These results suggest Tp0155 and Tp0483 are fibronectin-binding proteins mediating T. pallidum-host interactions. |
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