Nucleolytic action of chondroitinase ABC on the lumbar disc of the rabbit |
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| Authors: | N Henderson V Stanescu J Cauchoix |
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| Affiliation: | Institut de Recherche sur les Maladies du Squelette, Berck-sur-Mer. |
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| Abstract: | Nucleolysis using chondroitinase ABC was studied using the rabbit's intervertebral lumbar disc. The purpose was to find a possible alternative to chymopapain which is commonly used in the management of sciatica due to disc herniation. The injection of 1 U of the enzyme into the nucleus pulposus gave significant histological and biochemical changes in all twelve discs studied. |
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