Incorporation of radiolabel from [1-14C]5-hydroperoxy-eicosatetraenoic acid into slow reacting substance |
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| Authors: | C W Parker D Koch M M Huber S F Falkenhein |
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| Affiliation: | 1. Howard Hughes Medical Institute Laboratory St. Louis, Missouri 63110 USA;2. Department of Internal Medicine Division of Allergy and Immunology Washington University School of Medicine St. Louis, Missouri 63110 USA |
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| Abstract: | When synthetic [1-14C]5-hydroperoxy-eicosatetraenoic acid was incubated with rat basophilic cells, incorporation of the radiolabel into slow reacting substance (SRS) could be demonstrated as evidenced by comigration of spasmogenic activity and radioactivity after purification by high pressure liquid chromatography. This provides direct evidence that SRS is a product of the lipoxygenase pathway. |
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| Keywords: | Address reprint requests to Dr. Parker. |
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