Aberrant receptor-mediated Cushing's syndrome |
| |
Authors: | Bertagna Xavier Groussin Lionel Luton Jean-Pierre Bertherat Jérôme |
| |
Affiliation: | Service des Maladies Endocriniennes et Métaboliques, H?spital Cochin, Paris, France. xavier.bertagna@cch.ap-hop-paris.fr |
| |
Abstract: | Multiple alterations of G-protein-coupled receptors and G-proteins regulating intracellular transduction signal have been described in endocrine tumours. In Cushing's syndrome, aberrant or 'illicit' expression of membrane receptors (mainly G-protein-coupled receptors) has been observed in adrenal adenomas and adrenocorticotropic hormone (ACTH)-independent macronodular bilateral adrenal hyperplasia. The best characterized example to date is the aberrant expression of the gastric inhibitory polypeptide receptor that causes 'food-dependent hypercortisolism'. Aberrant expression of the luteinizing hormone, 2-adrenergic, interleukin receptors have also been reported. The level of expression of the vasopressin V1a receptor correlates with the direct (ACTH-independent) cortisol response to vasopressin. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|