Hungarian surveillance of germinal mutations |
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Authors: | Andrew Czeizel |
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Institution: | (1) Department of Human Genetics and Teratology, WHO Collaborating Center for the Community Control of Hereditary Diseases, National Institute of Hygiene, Gyáli ut 2-4, H-1966 Budapest, Hungary |
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Abstract: | Summary The Hungarian surveillance of germinal mutations is based on three indicator conditions seen in offspring, i.e., 15 sentinel anomalies, Down syndrome and component anomaly pairs of unidentified multiple congenital anomalies. It is an opportunistic program, because the necessary data are available from the Hungarian Congenital Malformation Registry. This system is described and the criteria of a good registry are summarized. The analysis of indicator conditions caused by germinal mutations did not reveal any measurable mutagenic effects in Hungary following the accident at the Chernobyl nuclear power plant. The pros and cons of germinal mutation surveillance are discussed. |
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