Pullulan: biosynthesis,production, and applications |
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| Authors: | Kuan-Chen Cheng Ali Demirci Jeffrey M Catchmark |
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| Institution: | (1) Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan;(2) Department of Agricultural and Biological Engineering, The Pennsylvania State University, University Park, State College, PA, USA;(3) The Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, State College, PA 16802, USA; |
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| Abstract: | Pullulan is a linear glucosic polysaccharide produced by the polymorphic fungus Aureobasidium pullulans, which has long been applied for various applications from food additives to environmental remediation agents. This review
article presents an overview of pullulan’s chemistry, biosynthesis, applications, state-of-the-art advances in the enhancement
of pullulan production through the investigations of enzyme regulations, molecular properties, cultivation parameters, and
bioreactor design. The enzyme regulations are intended to illustrate the influences of metabolic pathway on pullulan production
and its structural composition. Molecular properties, such as molecular weight distribution and pure pullulan content, of
pullulan are crucial for pullulan applications and vary with different fermentation parameters. Studies on the effects of
environmental parameters and new bioreactor design for enhancing pullulan production are getting attention. Finally, the potential
applications of pullulan through chemical modification as a novel biologically active derivative are also discussed. |
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