Ultrasound tracking for intra-fractional motion compensation in radiation therapy |
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| Institution: | 1. Mediri GmbH, Heidelberg, Germany;2. GSI Helmholtzzentrum für Schwerionenforschung GmbH, Darmstadt, Germany;3. Heidelberg Ion-Beam Therapy Center (HIT) and Department of Radiation Oncology, Heidelberg University Hospital, Germany;4. Ludwig Maximilian University, Munich, Germany;5. Fraunhofer MEVIS, Bremen, Germany;1. Biomedical Engineering Group, Department of Electrical Engineering, Technical University of Denmark, Building 349, DK-2800 Kgs Lyngby, Denmark;2. BK Medical Aps, Mileparken 34, DK-2730 Herlev, Denmark;3. Vicomtech-IK4, Paseo Mikeletegi 57, Parque Cientfico y Tecnológico de Gipuzkoa, Guipuzcoa, Spain;1. Department of Ultrasound Imaging and Interventions, Philips Research North America, Briarcliff Manor, NY;2. Department of Radiation Oncology, Sunnybrook Health Sciences Center, Toronto, ON, Canada;1. Institute of Biomechanics, Trauma Center Murnau, Prof.-Kuentscher-Str. 8, 82418 Murnau, Germany;2. Institute of Biomechanics, Paracelsus Medical University Salzburg, Strubergasse 21, Salzburg, Austria;3. Department of Mechanical Engineering, Boston University, 110 Cummington Mall, Boston, MA 02215, USA;4. Department of Mechanical and Biomedical Engineering, Boise State University, 1910 University Drive, Boise, ID 83725, USA;5. Clinical Research Imaging Centre, Queen''s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK;6. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong;1. Resident, Department of Oral and Maxillofacial Surgery, Louisiana State University School of Dentistry, New Orleans, LA, USA;2. Assistant Professor, Department of Oral and Maxillofacial Surgery, Louisiana State University School of Dentistry, New Orleans, LA, USA;1. Center for Vascular Diagnostics, Division of Vascular Surgery, University of Maryland School of Medicine, 22 South Greene Street, S10-B00, Baltimore, MD 21201;2. Department of Bioengineering, George Mason University, Fairfax, VA;3. Vascular Service, Veterans Affairs Medical Center, Baltimore, MD |
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| Abstract: | Modern techniques as ion beam therapy or 4D imaging require precise target position information. However, target motion particularly in the abdomen due to respiration or patient movement is still a challenge and demands methods that detect and compensate this motion. Ultrasound represents a non-invasive, dose-free and model-independent alternative to fluoroscopy, respiration belt or optical tracking of the patient surface. Thus, ultrasound based motion tracking was integrated into irradiation with actively scanned heavy ions. In a first in vitro experiment, the ultrasound tracking system was used to compensate diverse sinusoidal target motions in two dimensions. A time delay of ～200 ms between target motion and reported position data was compensated by a prediction algorithm (artificial neural network). The irradiated films proved feasibility of the proposed method. Furthermore, a practicable and reliable calibration workflow was developed to enable the transformation of ultrasound tracking data to the coordinates of the treatment delivery or imaging system – even if the ultrasound probe moves due to respiration. A first proof of principle experiment was performed during time-resolved positron emission tomography (4DPET) to test the calibration workflow and to show the accuracy of an ultrasound based motion tracking in vitro. The results showed that optical ultrasound tracking can reach acceptable accuracies and encourage further research. |
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| Keywords: | Ultrasound Motion correction Particle therapy |
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