RBE of ion beams in hypofractionated radiotherapy (SBRT) |
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| Affiliation: | 1. GSI Helmholtzzentrum für Schwerionenforschung (GSI), Dept. of Biophysics, Planckstrasse 1, D-64291 Darmstadt, Germany;2. Technische Universität Darmstadt, Darmstadt, Germany;1. Cavendish Laboratory, University of Cambridge, UK;2. Department of Oncology, University of Cambridge, UK;3. Cambridge University Hospitals NHS Foundation Trust, UK;1. German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany;2. Department of Radiation Oncology and OncoRay – National Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany;3. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA;4. Department of Radiation Oncology (Maastro), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands;5. Bernadottestr. 77, Hamburg, Germany;6. Institute of Radiation Oncology, Helmholtz Center Dresden-Rossendorf, Germany;1. Department of Oncology, Division of Radiation Oncology, McGill University, Montreal, Quebec, Canada;2. Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois;3. Department of Pathology, West Virginia University School of Medicine, Morgantown, West Virginia;4. Department of Radiation Oncology, West Virginia University School of Medicine, Morgantown, West Virginia;2. Department of Radiation Physics, The University of Texas, MD Anderson Cancer Center, Houston, TX;3. UC Irvine School of Medicine, Irvine, CA;1. Department of Oncology Physics, Edinburgh Cancer Centre, Western General Hospital, United Kingdom;2. Department of Clinical Oncology, Edinburgh Cancer Centre, Western General Hospital, United Kingdom;3. International Atomic Energy Agency, Vienna, Austria;4. The Christie NHS Foundation Trust, Manchester, United Kingdom;5. School of Engineering, the University of Edinburgh, the King’s Buildings, United Kingdom;1. Department of Radiation Oncology, Grand Metropolitan Hospital, Reggio Calabria, Italy;2. Department of Medical Physics, Grand Metropolitan Hospital, Reggio Calabria, Italy |
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| Abstract: | An important advantage for the application of carbon ion beams in tumour therapy is their increased relative biological effectiveness (RBE) as compared to conventional photon radiation. Since RBE among other factors depends on the dose level, the precise knowledge of the RBE dependence on the dose is of particular importance for the comparison of different fractionation schemes, involving different doses per fraction. Here we describe some general properties of the RBE vs. dose dependence, which are determined using a simple modelling approach based on the linear-quadratic model as well as a more sophisticated predictive model for the description of RBE. We show that for both approaches the systematic dependence of RBE on the cell or tissue type as characterized by the α/β-ratio of the photon linear quadratic parameters is expected to be inverted at high doses as compared to low doses.We demonstrate that this inversion is not a model specific feature, but a rather generic feature resulting from the linear-quadratic shape of dose response curves and the correlation between RBE and the photon α/β-ratio. The results are discussed with respect to other modelling approaches and to their implications for clinical applications of carbon ion beams using hypofractionated treatment schedules. |
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| Keywords: | Ion beam therapy RBE Hypofractionation SBRT |
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