Spider silk fibroin enhances insulin secretion and reduces blood glucose levels in diabetic mice |
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| Institution: | 1. Institute of Entomology, College of Agriculture, Guizhou University, Guizhou 550025, China;2. Guizhou Biological Institute, Guizhou 550009, China;3. Department of Entomology and Agricultural Zoology, Benaki Phytopathological Institute, 8 St. Delta Street, 145 61 Kifissia, Greece;4. Department of Chemical Biology, Xingyi Normal University for Nationalities, Xingyi, Guizhou 562400, China;1. Department of Bioresource Sciences, Andong National University, Andong 760-749, Republic of Korea;2. Institute of Agricultural Science and Technology, Andong National University, Andong 760-749, Republic of Korea;3. Department of Functional Crop, National Institute of Crop Science, Milyang 627-803, Republic of Korea;4. Greenagrotech, Kyeongsan 712-825, Republic of Korea |
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| Abstract: | Fibroin silk proteins make up the cocoons of silkworms and spider webs and are rich in glycine and alanine residues. Recent studies have shown that silk fibroin hydrolysate from silkworms improves blood glucose and lipid metabolism. In the present study, we investigated the anti-diabetic effects of spider silk fibroin protein in type 2 diabetic mice. Recombinant AvMaSp-R, which consists of the 240 amino acid repetitive domain of major ampullate silk protein (AvMaSp) from the spider Araneus ventricosus, was produced in baculovirus-infected insect cells. We tested the effects of oral AvMaSp-R administration on serum insulin and blood glucose levels in diabetic mice and found that AvMaSp-R increases serum insulin levels and reduces blood glucose levels in diabetic mice. Consequently, our results are the first to provide evidence that silk fibroin protein from spiders enhances insulin secretion, which leads to reduced blood glucose levels in type 2 diabetic mice. |
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