Spontaneous hepatitis C viral clearance and hepatitis C chronic infection
are associated with distinct cytokine profiles in Mexican patients |
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| Authors: | Nora A Fierro Karina González-Aldaco Rafael Torres-Valadez Maria E Trujillo-Trujillo Sonia Roman Jorge L Trujillo-Ochoa Arturo Panduro |
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| Affiliation: | 1.Unidad de Inmunovirología;3.Servicio de Biología Molecular en Medicina, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, México;2.Departamento de Fisiologia;4.Departamento de Biología Molecular;5.Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, México |
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| Abstract: | The mechanisms related to the spontaneous clearance of hepatitis C virus (HCV) havebeen primarily studied in regions where the infection is endemic. Results of priorstudies have been extrapolated to populations with low endemicity, such as Mexico.Herein, we determined the cytokine profiles in serum samples from Mexican patientswho spontaneously cleared HCV and patients chronically infected with HCV genotype 1a.Chronic HCV-infected patients displayed increased interleukin (IL)-8 and regulatedupon activation, normal T-cell expressed and secreted (CCL-5) secretion, whereaspatients who spontaneously cleared HCV showed augmented levels of IL-1 alpha, tumournecrosis factor-alpha, transforming growth factor-beta, monocyte chemoattractantprotein-2 (CCL-8), IL-13 and IL-15. Our study suggeststhat cytokine profiles maypredict disease outcome during HCV infection. |
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| Keywords: | hepatitis C virus cytokines viral clearance genotype 1a |
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