T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children

We determined the serum IgE levels and T-helper (Th)17-related cytokines duringdistinct hepatitis A virus (HAV)-induced clinical courses in children. Asignificantly higher concentration of macrophage inflammatory protein 3α, interleukin(IL)-17E and IL-17F in HAV-infected children with intermediate liver injury comparedwith those with minor liver damage was found. A reduction in the IgE levels in thosepatients who showed the highest levels of IL-17F in the group of intermediate liverinjury was found. The data suggested that the Th17-related profile is associated withthe severity of HAV infection and might play a role on the modulation achieved by HAVduring allergies.