| 中国苗族人群中细胞色素P450 2C19基因多态性的研究 |
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| 引用本文： | 张松,董兆文,周强.中国苗族人群中细胞色素P450 2C19基因多态性的研究[J].遗传,2001,23(3):192-194. |
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| 作者姓名： | 张松 董兆文 周强 |
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| 作者单位： | 1.国家计生委科学技术研究所分子生物研究室，北京 100081;2.贵州省计划生育科研所，贵阳 5500041.National Research Institute For Family Planning, Beijing 100081,Chian;2.Guizhou Research Institute For Family Planning, Guiyang 550004，China |
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| 基金项目： | 国家科技部计划生育专项基金资助，编号：998672 |
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| 摘 要： | 为研究细胞色素P4502C19在中国苗族人群中的基因型，采用聚合酶链式反应与限制性内切核酸酶片段长度多态性技术分析了98例无血缘关系苗族人群的基因型。结果显示50人为CYP2C19野生型纯合子（wt/wt）；39人为CYP2C19m1杂合子（wt/m1）；9人为CYP2C19m1突变型纯合子（m1/m1）。与国内外相关报道比较，本实验得出的CYP2C19m1突变频率与文献报道相符。
Abstract：In order to study the cytochrome P450 2C19 gene polymorphism in Miao population, the genotypes of ninety-eight unrelated Miao subjects were studied by polymera se chain reaction and restricted fragment length polymorphism (RFLP). The result s showed that fifty were homozygous for wild-type (wt/wt); thirty-nine wer e heterozygous for the CYP2C19m1 (wt/m1);nine were homozygou s for CYP2C19m1(m1/m1).The frequency of CYP2C19m1 was in agreement with that of other published data.
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| 关 键 词： | 限制性内切核酸酶片段长度多态 Keywords cytochrome P450 2C19 基因型 聚合酶链式反应 细胞色素P4502C19 |
| 文章编号： | 0253-9772(2001)03-0192-03 |
| 修稿时间： | 2000年5月18日 |
Cytochrome P450 2C19 Gene
Polymorphism in Chinese Miao Populat ion |
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| ZHANG Song,DONG Zhao-wen,ZHOU Qiang.Cytochrome P450 2C19 Gene
Polymorphism in Chinese Miao Populat ion[J].Hereditas,2001,23(3):192-194. |
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| Authors: | ZHANG Song DONG Zhao-wen ZHOU Qiang |
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| Abstract: | In order to study the cytochrome P450 2C19 gene polymorphism in Miao population, the genotypes of ninety-eight unrelated Miao subjects were studied by polymera se chain reaction and restricted fragment length polymorphism (RFLP). The result s showed that fifty were homozygous for wild-type (wt/wt); thirty-nine wer e heterozygous for the CYP2C19m1 (wt/m1);nine were homozygou s for CYP2C19m1(m1/m1).The frequency of CYP2C19m1 was in agreement with that of other published data. |
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